(Jan. 18, 2018) – Jennifer Sanner , Ph.D., R.N., Cizik School of Nursing’s Nancy B. Willerson Distinguished Professor and associate professor in the Department of Acute and Continuing Care, is lead author of a new article in Biological Research for Nursing now available online.  Interestingly, her co-authors include two UTHealth deans: Eric Boerwinkle, Ph.D., dean of The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, and Cizik School of Nursing Dean Lorraine Frazier, Ph.D., R.N., FAAN.

Jennifer Sanner, Megan L. Grove, Erica Yu, F. Gerard Moeller, Stanley G. Cron, Eric Boerwinkle, Alanna C. Morrison, Lorraine Frazier. Effects of Gender-Specific Differences, Inflammatory Response, and Genetic Variation on the Associations Among Depressive Symptoms and the Risk of Major Adverse Coronary Events in Patients With Acute Coronary Syndrome. Biological Research for Nursing (Jan. 3, 2018) DOI: 10.1177/1099800417751662 [Epub ahead of print]

The researchers sought to determine whether genetic- and/or gender-specific phenotypic differences contribute to associations among depressive symptoms, inflammatory response, and risk of major adverse coronary events (MACEs) in patients with acute coronary syndrome (ACS).  The study included 1,117 ACS patients to test a gender-specific model in which depressive symptoms are associated with risk of MACE. 

Findings suggested that the association between positive depressive symptom status and MACE did not vary by gender. However, the authors noted that “it remains of interest to identify a high-risk subgroup of ACS patients with genetic polymorphisms that result in immunoinflammatory dysregulation in the presence of depressive symptoms.”