- Research team: Principal investigator Diane Santa Maria, DrPH, MSN, RN, ACRN, PHNA-BC, FSAHM, FAAN. Co-Investigators Nikhil Padhye, PhD, of Cizik School of Nursing; Michael Businelle, PhD, of Oklahoma Health Science Center; and Natasha Slesnick, PhD, of The Ohio State University
- Funding sponsor: National Institute of Nursing Research (NINR)
- Overview: This study expands testing of a mobile health intervention aimed at HIV prevention among youth experiencing homelessness.
- Budget: $1,443,905
- Project period: Sept. 21, 2023 through 2027
Recently Completed Projects
Adapting a Mindfulness-based Stress Reduction Intervention for Emotion Regulation and Impulsivity in Homeless Youth: A Pilot Project (1R34AT010672-01A1)
- Research team: Principal Investigator
- Funding sponsor: National Center for Complementary and Integrative Health
- Overview: This project tested a tailored approach to mindfulness-based interventions designed for delivery to youth in homeless shelters.
- Budget: $731,783.
- Project period: September 2020 – August 2024
Come As You Are - Assessing the Efficacy of a Nurse Case Management HIV Prevention and Care Intervention Among Homeless Youth
- Research Team: Diane Santa Maria, DrPH, MSN, RN, ACRN, PHNA-BC, FSAHM, FAAN & Nikhil Padhye, PhD (Cizik School of Nursing); Adeline Nyamathi, ANP, PhD, FAAN (University of California Irvine); Marguerita Lightfoot, PhD (University of California San Francisco); Mary Paul, MD (Baylor College of Medicine); Yasmeen Quadri, MD (Healthcare for the Homeless Program of Harris County).
- Funding sponsor: National Institute of Nursing Research
- Overview: The purpose of this randomized wait-list control trial was to test the efficacy of a nurse case management HIV prevention intervention (called CAYA [Come As You Are]) compared to usual care among youth experiencing homelessness aged 16-25 years old. The intervention incorporates motivational interviewing strategies combined with nurse case management and a smartphone-based daily diary and goal feature to develop and monitor participant-driven HIV prevention behavioral goals.
- Budget: $3,085,854
- Project period: Jan. 9, 2019 - May 31, 2024
CAYA supplement studies:
Come As You Are (CAYA) Pre-Exposure Prophylaxis (PrEP) adherence study
- Overview: This study aims to enrich the scientific understanding of PrEP adherence and barriers and access to HIV prevention health services among sexual and gender minority (SGM) youth experiencing homelessness (YEH). Recruitment of this hard-to-reach, understudied population of high-risk youth provides an exceptional opportunity to examine engagement of SGM homeless youth in PrEP adherence measurement, qualitatively assess barriers and facilitators to access to and engagement in HIV prevention and care, and assess the role of stress on risk behaviors among SGM YEH.
Assessment of COVID-19 antibodies and transmission reduction strategies among Youth Experiencing Homelessness
- Overview: Participants for this supplement (YEH 16-25 years old) are recruited from sites already participating in the parent CAYA To meet the additional aims of this supplement, measures related to knowledge of and adherence to COVID-19 transmission reduction strategies (i.e. hand washing, masking, social distancing, stay-at home orders) were added to existing measures for mental health symptoms (i.e. stress, distress, anxiety), behavioral risks (i.e. condomless sex, trade sex, drug use), and determinants of health (i.e. housing). Additionally, COVID-19 antibody is conducted testing.
Related Publications:
Santa Maria D, Nyamathi A, Lightfoot M, Paul M, Quadri Y, Padhye N, Businelle M, Fernandez-Sanchez H, Torres Jones J. Results of a Randomized Wait-List Controlled Trial of CAYA: A Nurse Case Management HIV Prevention Intervention for Youth Experiencing Homelessness. Aids and Behavior. 2024. https://doi.org/10.1007/s10461-024-04544-3
Santa Maria D, Padhye N, Ostrosky-Zeichner L, Grimes C, Nyamathi A, Lightfoot M, Quadri Y, Paul M, Jones J. COVID-19 Vaccination Uptake, Infection Rates, and Seropositivity Among Youth Experiencing Homelessness in the United States. Nursing Research. 2024;73(5):373-380. https://doi.org/10.1097/NNR.0000000000000747
Santa Maria DM, Fernandez-Sanchez H, Nyamathi A, Lightfoot M, Quadri Y, Paul M, Jones JT. Lessons learned from conducting a community-based, nurse-led HIV prevention trial with youth experiencing homelessness: Pivots and pitfalls. Public Health Nursing. 2024;41:806–814. https://doi.org/10.1111/phn.13314
Santa Maria D, Lightfoot M, Nyamathi A, Businelle M, Paul M, Quadri Y, Padhye N, Jones J, Calvo Armijo M. A Nurse Case Management HIV Prevention Intervention (Come As You Are) for Youth Experiencing Homelessness Protocol for a Randomized Wait-List Controlled Trial. JMIR Research Protocols. 2021;10(5), e26716. doi:10.2196/26716
